Issue of Equity

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that it has agreed to issue 25,131 New Ordinary Shares of 0.1p each (‘New Ordinary Shares’) at a price of 95.5p (the ‘Issue Price’) to Hansard Communications Limited in respect of annual advisory fees. The Issue Price represents a premium of 29.93 per cent. to the closing share price of 73.5p as at 12 January 2011.

Admission and commencement of dealings in the New Ordinary Shares are expected to take place at 8.00 a.m. on 19 January 2011. There will be a total of 15,951,790 Ordinary Shares in issue following Admission of the New Ordinary Shares.

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant + 44 (0)207 245 1100

Hansard Communications
Kirsty Corcoran + 44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews/Tom Rowley + 44 (0)161 831 1512

Matrix Corporate Capital LLP - Joint Broker
Robert Naylor/Stephen Waterman +44 (0)20 3206 7340

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

AGM Statement

At the Annual General Meeting of Scancell Holdings Plc, (AIM: SCLP), to be held later today, David Evans, Chairman will give shareholders an update and review of the business. This will include the following statement:

This has been an exciting and busy year for Scancell in which the Company has successfully achieved all of its commercial and scientific aims in line with its strategy. Of particular note is the successful progression of Scancell’s first vaccine, SCIB1 for melanoma, which entered clinical trials in June 2010. The Company also successfully raised £2.5 million in April 2010 and moved from PLUS to AIM in July 2010.

SCIB1 Phase I Clinical Trial

Clearly, a move into clinical trials for SCIB1 represents an important milestone. This followed Clinical Trial Approval from the Gene Therapy Advisory Committee and by the Medicines and Healthcare Products Regulatory Agency Medicines Division. The approvals enabled Scancell to commence its Phase I clinical trial of SCIB1 in June 2010, to evaluate the safety and tolerability of SCIB1 in patients with late stage melanoma. To date, four patients have been enrolled on the trial which is currently taking place at three centres. Recruitment has been slower than anticipated due to the fact that a number of patients with advanced melanoma - the patients we require - are either being recruited into B-raf* studies or offered ipilimumab** on a compassionate use basis. By the time the patients have failed to respond to either (or both) of these treatments, they are often too ill to enter our study. Overall this has had an impact on the recruitment rates for the Phase I study, however the Company still expects to complete the clinical trial by the end of 2012.

To accelerate the advancement of the trial, two further centres will be opened, and Scancell has also filed protocol amendments to recruit patients with less severe disease. These earlier stage patients should make better immune responses which should ultimately have a positive effect on the outcome on our trial. The issue of patient recruitment is not expected to apply to the Phase II trial which will be conducted in less severely ill patients. The delay to patient recruitment may also have resource implications. Without Phase I clinical results (due in late 2011), it may be difficult to generate revenues from a commercial deal on the ImmunoBody® technology and it may therefore be necessary to augment the Company’s capital resources to complete the Phase II study.

Agreements and Collaborations

Scancell secured two key agreements during the year: a worldwide non-exclusive licensing agreement with the National Institutes of Health, an agency of the United States Department of Health and Human Services, for use of two melanoma antigens as key components of SCIB1; and, a licensing agreement with Cancer Research Technology Ltd, Cancer Research UK's commercialisation and development arm to use a human antibody for the development of new ImmunoBody® vaccines for any immunotherapy indication.

The Company also entered two important strategic collaborations: with ImmuneRegen BioSciences, Inc.®, a wholly owned subsidiary of IR BioSciences Holdings, Inc. (OTC BB:IRBS.OB) to investigate the synergy between ImmuneRegen's Homspera® and Scancell's ImmunoBody® vaccine technologies; and with immatics biotechnologies GmbH to explore the development of novel ImmunoBody® vaccines for colorectal cancer.

The Directors are pleased with Scancell’s progress during 2010 and look forward to updating shareholders on the future advancements in due course.

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant + 44 (0)207 245 1100

Hansard Communications
Kirsty Corcoran + 44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews/Tom Rowley + 44 (0)161 831 1512

Matrix Corporate Capital LLP - Joint Broker
Robert Naylor/Stephen Waterman +44 (0)20 3206 7340

Notes to Editors

During the past year, data has emerged from studies of two new treatments in Stage IV patients.

* Firstly, a study of a B-raf inhibitor in patients with advanced melanoma demonstrated tumour regression in 80% of patients (although this did not result in a long-term survival advantage).

** Secondly, a Phase III trial of the anti-CTLA4 monoclonal antibody ipilimumab has demonstrated prolonged survival of Stage IV melanoma patients, with 23.5% still alive after two years. This is the first drug to have a positive impact on survival and is likely to receive approval for use in patients with advanced metastatic melanoma next year. Even if this drug is approved, this still leaves 75% of patients with no appropriate therapy and in potential need of our vaccine.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Result of AGM

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that at the Annual General Meeting, held earlier today, all resolutions were duly passed.

For further information contact:

Scancell Holdings Plc

  • Professor Lindy Durrant - + 44 (0)207 245 1100

Hansard Communications

  • Kirsty Corcoran - + 44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker

  • Ross Andrews/Tom Rowley - + 44 (0)161 831 1512

Matrix Corporate Capital LLP - Joint Broker

  • Robert Naylor/Stephen Waterman - +44 (0)20 3206 7340

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Collaboration With ImmuneRegen BioSciences® Yields Positive Results in Cancer Vaccine Studies

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that a treatment utilising a DNA vaccine based on its ImmunoBody® technology, in combination with ImmuneRegen BioSciences, Inc.®’s lead compound, Homspera®, has significantly improved the immune response of the vaccine in an animal model. Follow-up studies are currently being performed to optimize the effects of Homspera in enhancing the next generation of Scancell’s cancer vaccines.

Scancell recently announced the commencement of a Phase I clinical trial utilizing its SCIB1 product being developed for the treatment of melanoma. SCIB1 is a novel DNA vaccine being developed using Scancell’s patented ImmunoBody® technology. ImmunoBody® vaccines generate the high-avidity T-cells that kill cancer cells, which may overcome the current limitations of most cancer vaccines. A unique advantage of Scancell’s Immunobody® technology is that it specifically targets dendritic cells, leading to a significant enhancement of the immune response.

ImmuneRegen’s Homspera has previously been found to improve the efficacy of a melanoma cancer vaccine in mice, resulting in persistent and specific immune responses associated with inhibition of melanoma tumor growth. Additionally, previous studies have demonstrated efficacy of Homspera in enhancing immune responses to infectious disease vaccines, such as influenza. Both applications are being aggressively developed by ImmuneRegen in combination with significant academic and industry partners.

Professor Lindy Durrant, Chief Executive Officer of Scancell, commented:

“I am pleased with the results achieved by this collaboration to date and look forward to continuing to work with ImmuneRegen as we progress with follow-up studies.”

Hal Siegel Ph.D., Chief Scientific Officer of ImmuneRegen, commented:

“We are pleased to see if we can positively augment immune responses elicited by Scancell’s ImmunoBody® vaccines. Based on our previous demonstration of enhanced dendritic cell responses to TRP2-encoding DNA vaccine following Homspera exposure, Scancell’s ImmunoBody® vaccine technology presents a very desirable developmental opportunity. We are very happy with our ongoing relationship and recognize that ongoing studies could potentially benefit both companies.”

ImmuneRegen BioSciences, Inc.® is a wholly owned subsidiary of IR
BioSciences Holdings, Inc. (OTC BB:IRBS.OB)

For further information contact:

Scancell Holdings Plc - Professor Lindy Durrant

  • + 44 (0)207 245 1100

Hansard Communications - John Bick/Kirsty Corcoran

  • + 44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker - Ross Andrews/Tom Rowley

  • + 44 (0)161 831 1512

Matrix Corporate Capital LLP - Joint Broker - Robert Naylor/Stephen Waterman

  • +44 (0)20 3206 7340

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

View the full Document

Appointment of Broker

The Board of Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announce the appointment of Matrix Corporate Capital LLP as joint broker with immediate effect.

For further information contact:

Professor Lindy Durrant - Scancell Holdings Plc

  • + 44 (0)207 245 1100

John Bick/Kirsty Corcoran - Hansard Communications

  • + 44 (0)207 245 1100

Ross Andrews/Tom Rowley - Zeus Capital - Nominated Adviser/Joint Broker

  • + 44 (0)161 831 1512

Robert Naylor/Stephen Waterman - Matrix Corporate Capital LLP - Joint Broker

  • +44 (0)20 3206 7340

View the full Document

Appointment of COO

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines which was admitted to trading on AIM on 30 July 2010, today announces that Dr Richard Goodfellow has been appointed to the role of Chief Operating Officer. Dr Goodfellow has been a key member of the Company’s management team and a member of the Board since 1999 and was previously Commercial Director of the Company.

David Evans, Chairman of Scancell, said:

“I am very pleased to announce Richard's appointment to the position of Chief Operating Officer. Scancell will continue to benefit from the skills and experience that Richard brings to the Company as it moves forward to achieve its stated objectives.”

For further information contact:

Professor Lindy Durrant  -  Scancell Holdings Plc

+44 (0)207 245 1100

John Bick/Kirsty Corcoran  -  Hansard Communications

+44 (0)207 245 1100

Ross Andrews  -  Zeus Capital

+44 (0)161 831 1512

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and is expected to enter clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Antibody Licence Agreement with Cancer Research Technology

Scancell Holdings Plc, (AIM:SCLP), the developer of therapeutic cancer vaccines, and Cancer Research Technology Ltd (‘CRT’) - Cancer Research UK’s commercialisation and development arm today announce that they have signed an agreement under which Scancell has been granted a licence to use a human antibody known as 105AD7.

105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55. The antibody was discovered and originally developed at the University of Nottingham with support from Cancer Research UK and has previously been evaluated in clinical trials for osteosarcoma. The agreement will give Scancell a worldwide licence to use 105AD7 for the development of new ImmunoBody® vaccines for any immunotherapy indication. The licence will be restricted to the use of the antibody as a framework for future ImmunoBody® vaccines.

Scancell’s current ImmunoBody® vaccines, such as SCIB1, its vaccine currently in Phase I clinical trials for the treatment of melanoma, use a deimmunised* antibody as the framework. 105AD7 will allow Scancell to use a fully human framework for the development of future ImmunoBody® vaccines.

Under the terms of the agreement, Scancell will make an upfront payment to CRT in addition to development milestone payments, and royalty payments on future sales. Scancell will exclusively fund the development work, and have sub-licensing rights on agreed terms.

Professor Lindy Durrant, Chief Executive Officer of Scancell, commented:

“I am pleased that we have secured this important agreement with Cancer Research Technology. By utilising antibody 105AD7, Scancell will be able to further enhance the clinical utility and safety of Scancell’s ImmunoBody® platform both in cancer and other immunotherapy indications.”

Dr Phil L’Huillier, Cancer Research Technology’s director of business management, said:

“Through this deal with Scancell we are able to take forward this antibody arising from research from our worldclass scientists into commercial development to potentially make new vaccines to treat a range of diseases.”

*Deimmunization is a technology for location and removal of T-cell epitopes through the combined use of immunological and molecular biology techniques to reduce the immunogenicity of an antibody.

For further information contact:

Professor Lindy Durrant Scancell Holdings Plc

  • + 44 (0)207 245 1100

John Bick/Kirsty Corcoran Hansard Communications

  • + 44 (0)207 245 1100

Ross Andrews/Tom Rowley Zeus Capital

  • + 44 (0)161 831 1512

 

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

About Cancer Research Technology Ltd

Cancer Research Technology Limited (CRT) is a specialist commercialisation and development company, which aims to develop new discoveries in cancer research for the benefit of cancer patients. CRT works closely with leading international cancer scientists and their institutes to protect intellectual property arising from their research and to establish links with commercial partners. CRT facilitates the discovery, development and marketing of new cancer therapeutics, vaccines, diagnostics and enabling technologies. CRT is wholly owned by Cancer Research UK, the largest independent funder of cancer research in the world.

CRT's discovery laboratories build on exploratory research to create attractive commercial opportunities through collaboration with research institutes worldwide. Therapeutic programmes are then out-licensed for further development following identification of a suitable partner.

For more information visit the web site www.cancertechnology.com

About Cancer Research UK

Cancer Research UK is the world’s leading charity dedicated to beating cancer through research.

The charity’s groundbreaking work into the prevention, diagnosis and treatment of cancer has helped save millions of lives. This work is funded entirely by the public.

Cancer Research UK has been at the heart of the progress that has already seen survival rates double in the
last forty years.

Cancer Research UK supports research into all aspects of cancer through the work of more than 4,800
scientists, doctors and nurses.

Together with its partners and supporters, Cancer Research UK's vision is to beat cancer.

For further information about Cancer Research UK's work or to find out how to support the charity, please call
020 7121 6699 or visit www.cancerresearchuk.org.uk

Grant of Options

Scancell Holdings plc, (PLUS:SCLP), the developer of therapeutic cancer vaccines, announces, further to the preliminary results announcement and the announcement of the Company’s proposed admission to AIM which were issued earlier today, the grant of share options to the Executive Directors of the Company under the EMI share option scheme.

In order to properly incentivise the Executive Directors, the Company has adopted an EMI Option Scheme. Under the terms of the EMI Option Scheme, each of Professor Lindy Durrant and Dr Richard Goodfellow have been granted options over Ordinary Shares of 1p each in the share capital of the Company.

The exercise price of the options is 45p; the same price at which new Ordinary Shares were issued under the Open Offer that was completed in March 2010. The Company has not been able to grant the options since the close of the Open Offer due to it being in a close period since that date. The exercise price represents a discount of approximately 28 per cent. to the middle market price of the Company’s Ordinary Shares at the close of business on 13 July 2010 which was 62.5p. Details of the EMI Options granted are set out in the table below:

Executive Director Number of EMI Options Exercise Price Expiry Date Vesting criteria
Professor Lindy Durrant 385,000 45p 31.12.15 Conditional on the Company being sold for > £25 million
Dr Richard Goodfellow 288,000 45p 31.12.15 Conditional on the Company being sold for > £25 million

The Directors of the issuer accept responsibility for this announcement.

For further information contact:

Professor Lindy Durrant, (CEO)  -  Scancell Holdings Plc:

  • +44 (0)207 245 1100

John Bick/Kirsty Corcoran  -  Hansard Communications

  • +44 (0)207 245 1100

Ross Andrews/Tom Rowley  -  Zeus Capital

  • +44 (0)161 831 1512

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and has recently entered clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Final Results for the year ended 30 April 2010

Scancell Holdings plc, (PLUS:SCLP), the developer of therapeutic cancer vaccines, announces its final results for the year ended 30 April 2010.

Highlights:

  • Strong progress in the development of the Company’s lead therapeutic melanoma vaccine SCIB1
  • Successful fundraising of £2.54 million (gross) during 2010
  • Loss before tax for the year of £1.80 million (2009: £0.8 million)
  • Cash at year end of £2.83 million
  • Since the year end the Company commenced Phase I/IIa clinical trials in humans for SCIB1

The Directors of the issuer accept responsibility for this announcement.

For further information contact:

Professor Lindy Durrant, (CEO)  -  Scancell Holdings Plc:

  • +44 (0)207 245 1100

John Bick/Kirsty Corcoran  -  Hansard Communications

  • +44 (0)207 245 1100
  • +44 (0)7872 061 007

Ross Andrews/Tom Rowley  -  Zeus Capital

  • +44 (0)161 831 1512

View the full document

Withdrawal from PLUS and Admission to AIM

The Board of Scancell Holdings plc, (PLUS:SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that it intends to apply for the Company’s Ordinary Shares to be admitted to trading on AIM and, immediately prior to the Admission to AIM, it intends to withdraw the Company’s Ordinary Shares from trading on PLUS.

During 2010, the Company has raised £2.54 million, before expenses, to fund its foreseeable working capital requirements. The Directors believe that the existing funds held by or available to the Group together with future anticipated revenues will be sufficient to allow completion of the Phase I/IIa clinical trial of SCIB1, its lead melanoma therapeutic vaccine.

The Ordinary Shares of the Company were originally admitted to trading on PLUS in September 2008. However, now that the Company has further strengthened its financial position and progressed the development of SCIB1, the Directors believe that it would be in the best interests of the Company and its shareholders for the Ordinary Shares to be admitted to trading on the AIM market of the London Stock Exchange.

The Directors believe that this represents a natural transition for the Company and that the potential benefits of an AIM listing will include an increased public profile for the Company.

Under the AIM Rules, prior to Admission, the Company is required to publish an admission document. The Company is therefore sending an admission document to Shareholders to inform them that the Ordinary Shares of the Company will be withdrawn from trading on PLUS from the close of business on 29 July 2010 and that the Ordinary Shares of the Company are expected to be admitted to trading on AIM at 8.00 a.m. on 30 July 2010.

The Directors of the issuer accept responsibility for this announcement.

For further information contact:

Professor Lindy Durrant, (CEO)  -  Scancell Holdings Plc:

  • +44 (0)207 245 1100

John Bick/Kirsty Corcoran  -  Hansard Communications

  • +44 (0)207 245 1100
  • +44 (0)7872 061 007

Ross Andrews/Tom Rowley  -  Zeus Capital

  • +44 (0)161 831 1512

View the full document