SCIB1 Trial Update

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce the completion of recruitment to the Phase I clinical trial of SCIB1, its DNA ImmunoBody® vaccine being developed for the treatment of melanoma. The trial is being conducted in five UK centres in patients with Stage III/IV disease, and it is anticipated that Phase II trials will commence in the next few weeks. 

Scancell has obtained approval from the Cohort Review Committee to commence the Phase II study using the 4mg dose, the highest dose used in the Phase I part of the study. The approval is based upon safety data collected after all patients have been treated for 6 weeks. The Phase I patients will continue to be treated and followed up for a total of 6 months. 

Professor Lindy Durrant, Joint CEO of Scancell Holdings and Professor of Cancer Immunotherapy at Nottingham University, commented: 

“The recruitment of patients to early stage cancer studies can be very challenging and it is a tribute to both the dedicated Scancell team and the efforts of our clinical investigators that we have now completed recruitment for the Phase I part of the study. We expect recruitment for Phase II to be substantially faster than for Phase I and hope to treat the first patient in this part of the study within the next few weeks.” 

For further information contact: 

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction

Holdings in Company

The Company announces that it has received notification that Helium Special Situations Fund Limited has a beneficial interest in Scancell Holdings of 15,556,940 ordinary shares of 0.1 pence each which represents approximately 8.0 per cent of the issued capital of the Company.

For further information contact: 

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall/ Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and entered clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Investor presentation 2012

This morning, at 11:00 am Scancell Holdings plc, (AIM: SCLP), will be hosting a presentation for investors and analysts. This presentation contains no new financial information and will be available from the Company’s website. www.scancell.co.uk

 Enquiries:

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

* calls to this number will reach Newgate Threadneedle, at Scancell's instruction

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

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Investor presentation (powerpoint)

ImmunoBody® Patent Approved in US

Scancell Holdings plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that its protein ImmunoBody® vaccine patent has been approved in the United States. The patent, which has already been approved in Europe and Australia, will further strengthen Scancell’s IP position around its proprietary ImmunoBody® vaccine platform.

Scancell’s lead vaccine, SCIB1 is being developed for the treatment of melanoma and is currently in Phase I clinical trials. It is an innovative DNA vaccine being developed using Scancell’s ImmunoBody® technology. Phase 2 trials are due to start in Q2 2012.

Dr. Richard Goodfellow, Joint Chief Executive of Scancell, commented:

“The USA remains the most important market in which to commercialise our ImmunoBody ® vaccines. The award of this US patent confirms the innovative nature of the ImmunoBody ® platform and provides a sound basis on which to commercialise the technology in the US.  Scancell will continue building its growing portfolio of intellectual property in parallel with driving the clinical trial programme forward during 2012”.  

Enquiries:

For further information contact: 

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and entered clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

 The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Change of Registered office

Scancell Holdings Plc, (AIM: SCLP), announces that the Company’s registered office address has changed to 2 More London Riverside, London, SE1 2AP with immediate effect.

Enquiries:

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9842*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9842
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle at Scancell's instruction.

Interim Results for the six month period to 31 October 2011

Scancell Holdings plc (“Scancell” or the “Company” or the “Group”), the developer of therapeutic cancer and infectious disease vaccines based on its patented Immunobody® platform, is pleased to announce the interim results for the six month period ended 31st October 2011.

Highlights:

  • Sub-division of share capital and Placing to raise £1.73 million;
  • Development of new vaccine candidate for the treatment of lung cancer;
  • Phase 1 clinical trial of SCIB1 proceeded to highest dose level following safety review;
  • SCIB1 patent awarded; and
  • Change of board structure.

Post Period Highlights:

  • Receipt of second tranche payment of £2.85 million in November 2011 relating to the sale of a portfolio of antibodies to Arana Therapeutics.

For further information contact:

Scancell Holdings Plc
Dr Richard Goodfellow / Professor Lindy Durrant
=44 (0) 20 7653 9842*

Newgate Threadneedle (Financial PR)
Guy McDougall / Heather Armstrong
+44 (0) 20 7653 9842

Zeus Capital - Nominated Adviser / Joint Broker
Ross Andrews / Tom Rowley
+44 (0) 161 831 1512

XCAP - Joint Broker
Jon Belliss / Adrian Kirk
+44 (0) 207 101 7070

*calls to this number will reach Newgate Threadneedle at Scancell's instruction.

View the full results 

Issue of Equity

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that it has agreed to issue 376,175 New Ordinary Shares of 0.1p each (`New Ordinary Shares') at a price of 6.38p (the `Issue Price') to Hansard Communications Limited in respect of annual advisory fees. The Issue Price represents a discount of 1.85 per cent. to the closing share price of 6.5p as at 12 December 2011.

Admission and commencement of dealings in the New Ordinary Shares are expected to take place at 8.00 a.m. on 19 December 2011. There will be a total of 194,469,485 Ordinary Shares in issue following Admission of the New Ordinary Shares.

For further information contact:

Scancell Holdings Plc
Dr Richard Goodfellow / Professor Lindy Durrant
+ 44 (0)207 245 1100*

Hansard (Financial PR)
Adam Reynolds/ Guy McDougall
+ 44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews/Tom Rowley
+ 44 (0)161 831 1512

XCAP - Joint Broker
Jon Belliss/ Adrian Kirk
+44 (0)207 101 7070

*calls to this number will reach Hansard, at Scancell’s instruction.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and entered clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Helium Special Situations increases interest in Scancell

Scancell Holdings Plc

(‘Scancell Holdings’ or the ‘Company’)

Holdings in Company

The Company announces that it has received notification that Helium Special Situations Fund Limited has increased its beneficial interest in Scancell Holdings to 17,586,940 ordinary shares of 0.1 pence each which represents approximately 9.06 per cent of the issued capital of the Company.

For further information contact:

Scancell Holdings Plc 

Professor Lindy Durrant/Dr Richard Goodfellow

+ 44 (0)207 245 1100

Hansard Communications- Financial PR 

Adam Reynolds/Guy McDougall

+ 44 (0)207 245 1100

Zeus Capital - Nominated Adviser

Ross Andrews/Tom Rowley

+ 44 (0)161 831 1512

XCAP Securities Plc - Broker

Jon Belliss/ Adrian Kirk

+44 (0) 207 101 7070

Confirmation of second tranche payment of £2.85 million from Arana Therapeutics

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that it has received confirmation from Cephalon, Inc that the condition relating to the second tranche payment from the sale of Scancell’s antibody portfolio to Arana Therapeutics in 2006 has now been satisfied. Scancell is therefore due to receive a further sum of £2.85 million (before any related tax and other costs are deducted) on 16 November 2011.

Background

On 1 December 2006, Scancell sold its portfolio of antibodies to Arana Therapeutics (then known as Peptech (UK) Limited and subsequently acquired by Cephalon, Inc, which itself is now owned by Teva Pharmaceutical Industries Limited). The consideration for the sale was a cash payment of £2 million, which was paid on completion of the sale, plus a possible further sum of £2.85 million gross which was payable when a milestone was achieved relating to the development of a drug derived from any of the antibodies which were the subject of the sale.

Confirmation that payment is due

Scancell has received confirmation from Cephalon, Inc that this milestone has been achieved and the condition for payment of the further sum of £2.85 million has therefore been satisfied.

The receipt of the second tranche payment is expected to trigger a payment to advisers of the Company and, under an executive incentivisation package agreed by the Board in June 2006, Professor Lindy Durrant, Dr Richard Goodfellow and Nigel Evans are entitled to receive gross bonuses calculated as a percentage of the net payment received by the Company. The total of these payments is not expected to exceed £450,000.

The £2.85 million gross proceeds from the second tranche payment will therefore be reduced by the payment of bonuses and adviser costs as noted above and does not take into account any corporation tax that may arise.

David Evans, Chairman of Scancell, said: "The confirmation that Scancell will receive the second tranche payment of £2.85 million from Arana Therapeutics is excellent news for the Company. We expect that the net funds to be received will enable the Company to complete the Phase I and Phase II clinical trials of our lead melanoma vaccine, SCIB1, without the need to raise further funds from Shareholders."

For further information contact:

Scancell Holdings Plc
Dr Richard Goodfellow / Professor Lindy Durrant
+44 (0)207 245 1100*

Hansard Group (Financial PR)
Adam Reynolds / Guy McDougall
+44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews / Tom Rowley
+44 (0)161 831 1512

XCAP - Joint Broker
John Belliss / Adrian Kirk
+44 (0) 207 101 7070

*this number will direct callers to Hansard Group, at Scancell's instruction.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Progress on possible second tranche payment from Arana Therapeutics

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to provide shareholders with an update on progress towards meeting the trigger for the second tranche payment from the sale of Scancell’s antibody portfolio to Arana Therapeutics in 2006.

On 1 December 2006, Scancell sold its portfolio of antibodies to Arana Therapeutics (then known as Peptech (UK) Limited and subsequently acquired by Cephalon Inc). The consideration for the sale was a cash payment of £2 million, which was paid on completion of the sale, plus a possible further sum of £2.85 million gross which is payable when the first patient is treated with a drug derived from any of the antibodies which were the subject of the sale, provided that this occurs prior to 6 December 2011.

A notification has recently appeared on ClinicalTrials.gov, a service of the US National Institutes of Health, confirming that a Phase 1 Study of CEP-37250 (formerly known as Scancell antibody SC104) in patients with advanced solid tumours is expected to commence in October 2011 in three US clinics.

The Phase 1 study has not yet commenced and there is no guarantee that it will commence in time to satisfy the milestone; it therefore cannot be assumed that the contingent consideration will be paid. Shareholders will be kept fully updated with any further developments.

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant
+44 (0)207 245 1100*

Hansard Group (Financial PR)
Adam Reynolds/Guy McDougall
+44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews/Tom Rowley
+44 (0)161 831 1512

XCAP - Joint Broker
John Belliss/Adrian Kirk
+44 (0) 207 101 7070

*this number will direct callers to Hansard Group, at Scancell's instruction.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.